Development and <i> In vitro</i> evaluation of buccoadhesive tablets of metoprolol tartrate
نویسندگان
چکیده
منابع مشابه
Lopressor® metoprolol tartrate tablets, USP, metoprolol tartrate injection, USP
Lopressor, metoprolol tartrate USP, is a selective beta1-adrenoreceptor blocking agent, available as 50and 100-mg tablets for oral administration and in 5-mL ampuls for intravenous administration. Each ampul contains a sterile solution of metoprolol tartrate USP, 5 mg, and sodium chloride USP, 45 mg, and water for injection USP. Metoprolol tartrate USP is (±)-1 (Isopropylamino)-3-[p-(2-methoxy...
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The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The polymer was incorporated into a matri...
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Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for in...
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In the present research work pulsatile drug delivery system of Metoprolol tartrate tablets were formulated and developed by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated table...
متن کاملFormulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers.
In view of the circadian rhythm of cardiovascular diseases, a delayed-onset extended-release (DOER) formulation of metoprolol tartrate (MT) was prepared. This was achieved through dissolution-guided optimization of the proportion of Methocel K4M and Methocel K15M. Core erosion ratio was greater than 50 %, thereby showing steady release of the drug after the lag time until complete dissolution. ...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2008
ISSN: 0250-474X
DOI: 10.4103/0250-474x.40349